Hi Kellie, while I can't speak to the difference between the programs I can tell you that I'm on Vista Business and LOVE it. It did take some getting used to (as I tend to go kicking and screaming with major software changes

) but it's really pretty seamless when you get right down to it and is a great operating system all the way around.
It can get buggy with Norton Antivirus but we just uninstalled that annoying little bugger right away and all issues disappeared.
I hope that helps a bit!
Also, here's a little
comparison chart at Buy.com that might help show some of the main differences.