It depends what your experience is?? Like Excel, Quickboks, Word, Access..Things like that. You can get certifications for all of these. Clients always like to know you have certifications.
Also the IVAA is a great place to registered with! There may be a Virtual Assistant Chamber of Commerce in your State!
My home office is completely equipped: fax computer, printer, computer, etc.. I tend to use them all

I use Excel on a weekly basis.
I can't speak enough pros of being a VA.. First and foremost, the skies the limit!! I have done so many different projects, that as along as you type well, are good on the internet, you can add VA Services..It does help having a niche, which it seems you do!!
I don't have negatives as far as being a VA. I love being a VA.. Building clients is the hard part. But with hard work, it can be done!!
Good Luck!