I agree with Kathie! Why go to so much trouble and expense when there are great programs online that will do it all for you - or at least simplify.

My personal favorite is Vertical Response, although I've also worked with Constant Contact.

I have not worked with AWeber, which is sort of amazing since it seems everyone else HAS - but have heard great things about it.

I just charge my regular hourly admin rate for the management of it all, and if I'm doing a custom HTML email newsletter then the speciality rate applies.