QuickBooks Pro! I have used many other programs and this is the only one I recommend. It's very important that you set everything up properly in the beginning to avoid having to re-do things later. QuickBooks has great free tutorials that will walk you through set-up step by step, but it is very user friendly and easy to learn regardless.
It always makes me cringe when I hear people say they do their bookkeeping by hand. It's so much easier doing it with a software like QuickBooks. You'll love it and never go back!