Hi Michelle,
I use MS Publisher, Adobe Illustrator, Adobe InDesign, and Adobe Photoshop. They are all great programs and depending on what a client needs I have the programs to do the job right
I use Publisher for The Virtual Entrepreneur ezine and then convert it to Adobe PDF. So, it is more like a magazine lol
Quark Express is another great tool that I use, but I have been asked for Illustrator more than Quark.
Take care,
Andrea~